Jolanta Pupure Selected Research

3-(2,2,2-trimethylhydrazine)propionate

5/2013	Mildronate enhances learning/memory and changes hippocampal protein expression in trained rats.
1/2013	Mildronate and its neuroregulatory mechanisms: targeting the mitochondria, neuroinflammation, and protein expression.
1/2012	Search for stroke-protecting agents in endothelin-1-induced ischemic stroke model in rats.
11/2010	Neuroprotective properties of mildronate, a small molecule, in a rat model of Parkinson's disease.
9/2008	Mitochondria as the target for mildronate's protective effects in azidothymidine (AZT)-induced toxicity of isolated rat liver mitochondria.
10/2006	Protection of azidothymidine-induced cardiopathology in mice by mildronate, a mitochondria-targeted drug.

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Jolanta Pupure Research Topics

Disease

5	Neuroinflammatory Diseases 08/2020 - 01/2013
4	Alzheimer Disease (Alzheimer's Disease) 08/2020 - 01/2018
3	Parkinson Disease (Parkinson's Disease) 04/2021 - 11/2010
3	Mitochondrial Diseases (Mitochondrial Disease) 01/2019 - 10/2006
3	Inflammation (Inflammations) 01/2013 - 10/2006
2	Cognitive Dysfunction 08/2020 - 01/2019
2	Dementia (Dementias) 01/2019 - 05/2013
2	Neurodegenerative Diseases (Neurodegenerative Disease) 05/2013 - 11/2010
2	Cardiotoxicity 11/2008 - 09/2008
1	Gliosis 08/2020
1	Type 2 Diabetes Mellitus (MODY) 08/2020
1	Ischemia 05/2013
1	Infarction (Infarctions) 01/2012
1	Ischemic Stroke 01/2012
1	Stroke (Strokes) 01/2012
1	Alcoholism (Alcohol Abuse) 04/2009
1	Anxiety Disorders (Anxiety Disorder) 04/2009
1	Muscular Diseases (Myopathy) 10/2006
1	Acquired Immunodeficiency Syndrome (AIDS) 10/2006

Drug/Important Bio-Agent (IBA)

6	3-(2,2,2-trimethylhydrazine)propionateIBA 05/2013 - 10/2006
4	Streptozocin (Streptozotocin)FDA Link 08/2020 - 01/2018
4	Acetylcholine (Acetylcholine Chloride)FDA Link 08/2020 - 01/2018
4	Zidovudine (Retrovir)FDA LinkGeneric 05/2013 - 10/2006
3	Pharmaceutical PreparationsIBA 08/2020 - 10/2006
3	gamma-Aminobutyric Acid (GABA)IBA 01/2019 - 01/2018
3	Proteins (Proteins, Gene)FDA Link 01/2019 - 01/2013
2	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 04/2021 - 11/2010
2	Oxidopamine (6 Hydroxydopamine)IBA 04/2021 - 11/2010
2	EsterasesIBA 08/2020 - 01/2018
2	Glucose (Dextrose)FDA LinkGeneric 08/2020 - 01/2019
2	MuscimolIBA 01/2019 - 01/2018
2	Glial Fibrillary Acidic ProteinIBA 01/2018 - 11/2010
2	EnzymesIBA 01/2018 - 09/2008
2	gamma-butyrobetaine (butyrobetaine)IBA 05/2013 - 01/2012
2	1,4-dihydropyridine (dihydropyridine)IBA 01/2012 - 11/2008
2	2,6- dimethyl- 3,5- bis(2'- propoxyethoxycarbonyl)- 4- (2''- difluoromethoxyphenyl)- 1,4- dihydropyridineIBA 01/2012 - 11/2008
2	Peptides (Polypeptides)IBA 11/2010 - 04/2009
2	Anti-HIV Agents (AIDS Drugs)IBA 11/2008 - 10/2006
1	Hypoglycemic Agents (Hypoglycemics)IBA 08/2020
1	Metformin (Glucophage)FDA LinkGeneric 08/2020
1	phthalic acid (phthalate)IBA 01/2019
1	Diethylhexyl Phthalate (DEHP)IBA 01/2019
1	Diazepam (Valium)FDA LinkGeneric 01/2019
1	GABA Receptors (GABA Receptor)IBA 01/2019
1	LigandsIBA 01/2019
1	Baclofen FDA LinkGeneric 01/2018
1	Glutamate Decarboxylase (Decarboxylase, Glutamate)IBA 01/2018
1	PropionatesIBA 05/2013
1	Nootropic Agents (Nootropics)IBA 05/2013
1	Neuroprotective AgentsIBA 05/2013
1	Endothelin-1 (Endothelin 1)IBA 01/2012
1	NeurotoxinsIBA 11/2010
1	Biomarkers (Surrogate Marker)IBA 11/2010
1	Proteasome Endopeptidase Complex (Proteasome)IBA 11/2010
1	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 11/2010
1	UbiquitinIBA 11/2010
1	glutapyroneIBA 11/2008
1	tauropyroneIBA 11/2008
1	NF-kappa B (NF-kB)IBA 09/2008
1	NucleosidesIBA 10/2006
1	Reverse Transcriptase InhibitorsIBA 10/2006

Therapy/Procedure

1	Therapeutics 10/2006